- British journal BMJ accuses Dr. Andrew Wakefield of faking data for his 1998 paper
- "The damage to public health continues" as a result of the autism-vaccine claim
- Vaccination rates dipped, measles cases increased after the study's publication
- The study was retracted and Wakefield lost his license in 2010
January 5, 2011 7:11 p.m. EST
Dr. Andrew Wakefield misrepresented or altered medical histories to bolster his 1998 study, an investigation found.
-- A now-retracted British study that linked autism to childhood vaccines was an "elaborate fraud" that has done long-lasting damage to public health, a leading medical publication reported Wednesday.
An investigation published by the British medical journal BMJ concludes the study's author, Dr. Andrew Wakefield, misrepresented or altered the medical histories of all 12 of the patients whose cases formed the basis of the 1998 study -- and that there was "no doubt" Wakefield was responsible.
"It's one thing to have a bad study, a study full of error, and for the authors then to admit that they made errors," Fiona Godlee, BMJ's editor-in-chief, told CNN. "But in this case, we have a very different picture of what seems to be a deliberate attempt to create an impression that there was a link by falsifying the data."
Britain stripped Wakefield of his medical license in May 2010. Efforts to reach him for comment were unsuccessful Wednesday.
"Meanwhile, the damage to public health continues, fueled by unbalanced media reporting and an ineffective response from government, researchers, journals and the medical profession," BMJ states.
The now-discredited paper panicked many parents and led to a sharp drop in the number of children getting the vaccine that prevents measles, mumps and rubella. Vaccination rates dropped sharply in Britain after its publication, falling as low as 80 percent by 2004. Measles cases have gone up sharply in the ensuing years.
In the United States, more cases of measles were reported in 2008 than in any other year since 1997, according to the Centers for Disease Control and Prevention. More than 90 percent of those infected had not been vaccinated or their vaccination status was unknown, the CDC reported.
"But perhaps as important as the scare's effect on infectious disease is the energy, emotion and money that have been diverted away from efforts to understand the real causes of autism and how to help children and families who live with it," the BMJ editorial states.
Wakefield has been unable to reproduce his results in the face of criticism, and other researchers have been unable to match them. Most of his co-authors withdrew their names from the study in 2004 after learning he had had been paid by a law firm that intended to sue vaccine manufacturers -- a serious conflict of interest he failed to disclose. After years on controversy, the Lancet, the prestigious journal that originally published the research, retracted Wakefield's paper last February...
The series of articles launched Wednesday are investigative journalism, not results of a clinical study. The writer, Brian Deer, said Wakefield "chiseled" the data before him, "falsifying medical histories of children and essentially concocting a picture, which was the picture he was contracted to find by lawyers hoping to sue vaccine manufacturers and to create a vaccine scare."
According to BMJ, Wakefield received more than 435,000 pounds ($674,000) from the lawyers. Godlee said the study shows that of the 12 cases Wakefield examined in his paper, five showed developmental problems before receiving the MMR vaccine and three never had autism.
"It's always hard to explain fraud and where it affects people to lie in science," Godlee said. "But it does seem a financial motive was underlying this, both in terms of payments by lawyers and through legal aid grants that he received but also through financial schemes that he hoped would benefit him through diagnostic and other tests for autism and MMR-related issues."
Dr. Max Wiznitzer, a pediatric neurologist at Rainbow Babies & Children's Hospital in Cleveland, said the reporting "represents Wakefield as a person where the ends justified the means." But he said the latest news may have little effect on those families who still blame vaccines for their children's conditions.
"Unfortunately, his core group of supporters is not going to let the facts dissuade their beliefs that MMR causes autism,"
Oh yeah, we all had measles as kids, so what's the problem? Well ....
Measles is a viral respiratory infection that attacks the immune system. Exceptionally contagious, children who are not immunized will suffer from the disease when exposed. Children under the age of five are most at risk. The disease infects close to 30 million children each year and kills almost 350,000
, usually from complications related to pneumonia, diarrhea and malnutrition. Survivors of measles are often left with life-long disabilities, such as blindness, deafness or brain damage...
Most deaths at the hands of measles are easily prevented through immunization at a cost of less than US $1 per child.